Measles Research Today is a free monthly online journal that collates and summarizes the latest research about Measles, including details on german measles, symptoms, vaccine, treatment, rubella.

Antiviral immune response in patients with multiple sclerosis and healthy siblings.

Comabella M, Montalban X, Horga A, Messmer B, Kakalacheva K, Strowig T, Caballero E, Münz C, Lünemann J

Centre d'Esclerosi Múltiple de Catalunya, CEM-Cat, Unitat de Neuroimmunologia Clínica, Hospital Universitari Vall d'Hebron (HUVH), Barcelona, Spain. mcomabel@ir.vhebron.net.

The objective of this study was to determine the immune responses to candidate viral triggers of multiple sclerosis in patients and healthy siblings raised in the same family household. Virus antigen-specific IgG responses to Epstein-Barr virus-derived gene products as well as to human herpersvirus-6, human cytomegalovirus, and measles virus were evaluated in 25 multiple sclerosis patients and compared with 49 healthy full-siblings. IgG responses to the latent Epstein-Barr virus-encoded nuclear antigen-1 (EBNA1) were selectively increased in individuals with multiple sclerosis compared with their unaffected siblings. We conclude that elevated IgG responses towards EBNA1 are associated with the development of multiple sclerosis.

Published 5 March 2010 in Mult Scler, 16(3): 355-8.
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Articles on Measles published 5 March 2010:

Origin of measles virus: divergence from rinderpest virus between the 11th and 12th centuries.   Virol J, 7(1): 52.

ABSTRACT: Measles, caused by measles virus (MeV), is a common infection in children. MeV is a member of the genus Morbillivirus and is most closely related to rinderpest virus (RPV), which is a pathogen of cattle. MeV is thought to have evolved in an environment where cattle and humans lived in close proximity. Understanding the evolutionary history of MeV could answer questions related to divergence times of MeV and RPV. We investigated divergence times using relaxed clock Bayesian ... [Abstract] [Full-text]

Intralesional immunotherapy of common warts: successful treatment with mumps, measles and rubella vaccine.   J Eur Acad Dermatol Venereol.

Abstract Background Despite numerous therapeutic modalities reported in the literature, treatment of common warts remains a continuing challenge and there is no universal consensus about optimal treatment. Recently, intralesional immunotherapy by different antigens has proved efficacy in the treatment of different types of warts. Objective To evaluate the efficacy and safety of intralesional mumps, measles and rubella (MMR) vaccine in the treatment of common warts. Methods The study included ... [Abstract] [Full-text]

Articles on Measles published 4 March 2010:

Interleukin-4 downregulates CD127 expression and activity on human thymocytes and mature CD8(+) T-cells.   Eur J Immunol.

Signalling via the IL-7 receptor complex (IL-7Ralpha/CD127 and IL-2Rgamma/CD132) is required for T-cell development and survival. Decreased CD127 expression has been associated with persistent viral infections (e.g. HIV, HCV) and cancer. Many IL-2Rgamma-sharing (gamma(C)) cytokines decrease CD127 expression on CD4(+) and CD8(+) T-cells in mice (IL-2, -4, -7, -15) and in humans (IL-2, -7) suggesting a common function. IL-4 is of particular interest as it is upregulated in HIV infection and in ... [Abstract] [Full-text]

Measles Virus-Induced Immunosuppression in SLAM Knock-In Mice.   J Virol.

Measles virus (MV) causes transient severe immunosuppression in patients, which may lead to secondary viral and bacterial infections largely accounting for measles-related morbidity and mortality. MV is known to infect immune cells by using the human signaling lymphocyte activation molecule (SLAM, also called CD150) as a cellular receptor, but the mechanism by which MV causes immunosuppression is not well understood. We show that MV infection of SLAM knock-in mice, in which the V domain of ... [Abstract] [Full-text]

Measles: Not just a childhood rash.   Cleve Clin J Med, 77(3): 207-13.

In recent years, the number of US measles cases has increased, and outbreaks in adults continue to be reported in communities with a high number of unvaccinated people. These trends underscore the need for high overall measles vaccination coverage, and for physicians to entertain the diagnosis of measles in adult patients with a febrile illness and rash. [Abstract] [Full-text]

Articles on Measles published 3 March 2010:

REACTOGENICITY AND IMMUNOGENICITY OF COMBINED HAEMOPHILUS INFLUENZAE TYPE B-MENINGOCOCCAL SEROGROUP C CONJUGATE VACCINE BOOSTER DOSE COADMINISTERED WITH MEASLES, MUMPS, AND RUBELLA VACCINEHIB-MENC-TT BOOSTER WITH ROUTINE MMR VACCINE.   Pediatr Infect Dis J, 29(3): 269-271.

A booster dose of Haemophilus influenzae type b-Neisseria meningitidis serogroup C conjugate (Hib-MenC-TT) vaccine simultaneously administered with measles, mumps, and rubella (MMR) vaccine in 13- to 14-month-old Spanish toddlers, primed with 3 doses of a combined Diphteria-Tetanus-Acellular Pertusis DTPa-Hib-containing vaccine and a MenC-CRM197 conjugate vaccine, had a good reactogenicity profile and induced similar Hib and MenC booster responses and MMR seropositivity rates as the vaccines ... [Abstract] [Full-text]

New Combination Vaccines: DTaP-IPV (Kinrix) and DTaP-IPV/Hib (Pentacel) (March) (CE).   Ann Pharmacother.

OBJECTIVE: To evaluate the clinical utility of diphtheria and tetanus toxoids and acellular pertussis adsorbed and inactivated poliovirus vaccine ([DTaP-IPV]; Kinrix) and diphtheria and tetanus toxoids and acellular pertussis adsorbed, inactivated poliovirus and Haemophilus b conjugate (tetanus toxoid conjugate) vaccine ([DTaP-IPV/Hib]; Pentacel) in the schedule for pediatric immunizations. DATA SOURCES: PubMed was searched (1966-April 2009) using the key words Kinrix and Pentacel. Subject ... [Abstract] [Full-text]

Articles on Measles published 2 March 2010:

Enhanced Antitumor Effects of an Engineered Measles Virus Edmonston Strain Expressing the Wild-type N, P, L Genes on Human Renal Cell Carcinoma.   Mol Ther, 18(3): 544-51.

Measles virus Edmonston strain (MV-Edm) is thought to have remarkable oncolytic activity that selectively destroys human tumor cells. The P/V/C protein of wild-type MV was shown to resist the antiviral effects of interferon (IFN)-alpha. Here, we engineered new MVs by arming MV-Edm tag strain (a V-defective vaccine-lineage strain, MV-Etag) with the P or N, P, and L genes of wild-type MV (MV-P and MV-NPL, respectively). The oncolytic activities of the MVs were determined in human renal cell ... [Abstract] [Full-text]

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